Life Itself centers on a couple that lead a multi generational love story spanning both decades and continents, from the streets of New York to the Spanish countryside, and are all connected by a single event.

A young couple must navigate a blossoming romance, amidst a war between their families' competing pizza restaurants.

Del (Peter Dinklage) is alone in the world. Literally. After the human race is wiped out, he lives in a small, empty town, methodically going from house to house, collecting batteries and other useful items, and burying the dead.

Haunted by nightmares of his torment, Louie sees himself as anything but a hero. Then, he meets Cynthia, a young woman who captures his eye...and his heart.

The story is about two mature couples with a long-term relationship.